Brian Barneclo
As soon as we stepped into NOPA on Saturday night, I was smitten with artist Brian Barneclo's work. His San Francisco neighborhood mural at the restaurant's entrance is fantastic. (Apparently, he lives just a couple doors down from Nopa.)
He's also done a room at the Hotel Des Arts, and some of his pieces are available at The Shooting Gallery. A more affordable way to purchase his work: He designed a collection of boxed chocolates for Recchiuti. (Psst ... So did another one of my local faves, Rex Ray.)

Photo from the Hotel Des Arts web site.
Photo from the SF Chronicle by Jim Merithew.